protein kinases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14860	CaMKII-IN-1		CaMK , Autophagy
	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.		CaMK , Autophagy
T3546	STO-609	STO 609	CaMK , AMPK , Autophagy
	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL).		CaMK , AMPK , Autophagy
T2697	KN-93		CaMK , Autophagy
	KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.		CaMK , Autophagy
TQ0137	A-484954	A 484954	CaMK , Parasite , Autophagy
	A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.		CaMK , Parasite , Autophagy
TP2310	Autocamtide-2-related inhibitory peptide		CaMK , Autophagy
	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.		CaMK , Autophagy
T6605	NH125		CaMK , Virus Protease , PKA , Antibacterial , PKC , Autophagy , Antifungal
	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T14069	A-3 hydrochloride		CaMK , Casein Kinase , PKA , PKC
	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv...		CaMK , Casein Kinase , PKA , PKC
T2694	KN-62		CaMK , P2X Receptor , Autophagy
	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.		CaMK , P2X Receptor , Autophagy
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T9305	Necroptosis-IN-1		RIP kinase
	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.		RIP kinase
T15437	GSK3145095		RIP kinase
	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.		RIP kinase
T3537	GSK583		RIP kinase
	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).		RIP kinase
T7795	RIPA-56		RIP kinase
	RIPA-56 is an inhibitor of RIP1		RIP kinase
T7151	GSK2982772		RIP kinase
	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.		RIP kinase
T6815	HS-1371		RIP kinase
	HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.		RIP kinase
T8574	SPHINX		Others
	SPHINX is a new generation inhibitor of SPRK1		Others
T10667	Calmidazolium chloride	R 24571	CaMK , Autophagy
	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 ...		CaMK , Autophagy
T9702	Eclitasertib		RIP kinase
	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).		RIP kinase
T3844	Deltonin		ERK , Others , Akt , Endogenous Metabolite
	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).		ERK , Others , Akt , Endogenous Metabolite
T8389	Trifluoperazine	trifluoroperazine	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.